該基因是尾相關同源盒轉錄因子基因家族的成員。編碼蛋白是參與細胞生長和分化的腸道特異性基因的主要調節因子。這種蛋白也在腸道的早期胚胎發育中起作用。這種基因的異常表達與腸道炎癥和腫瘤發生有關。
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.