這個基因編碼一種屬于Dickkopf家族的蛋白質。是一種具有兩個富含半胱氨酸區域的分泌蛋白，通過抑制Wnt信號通路參與胚胎發育。骨髓血漿和外周血中dkk1水平升高與多發性骨髓瘤患者存在溶骨性骨病變有關。
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.