該基因編碼的蛋白是蛋白酪氨酸磷酸酶（PTP）家族的成員。眾所周知，PTP是調節多種細胞過程的信號分子，包括細胞生長、分化、有絲分裂周期和致癌轉化。該PTP的N端部分包含兩個串聯的SRC同系物（SH2）結構域，作為蛋白磷酸-酪氨酸結合結構域，并介導該PTP與其底物的相互作用。這種PTP主要在造血細胞中表達，并作為造血細胞多種信號通路的重要調節因子。這種PTP已被證明與參與造血細胞信號傳導的廣譜磷酸蛋白相互作用并去磷酸化。該基因的多種選擇性剪接變體編碼不同的亞型，已被報道。
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.