這個基因編碼一種屬于芽科的蛋白質。編碼蛋白含有一個羧基末端富含半胱氨酸的結構域，對受體酪氨酸激酶信號蛋白的抑制活性至關重要，并且對于生長因子刺激的蛋白質向膜皺褶的易位是必需的。在原發性真皮內皮細胞中，該基因對成纖維細胞生長因子2的反應是短暫上調的。該蛋白間接參與了對成纖維細胞生長因子2信號傳導的非細胞自主抑制作用。該蛋白與cas-br-m（小鼠）電逆轉錄病毒轉化序列相互作用，可作為表皮生長因子受體/絲裂原活化蛋白激酶信號的雙峰調節器。該蛋白可能在肺發育過程中的肺泡分支中起作用，如小鼠蛋白所示。
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.