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  • 發布時間:2022-07-21 10:12 原文鏈接: 與干細胞標和分化信號通路相關因子介紹BCOR

    該基因編碼的蛋白被鑒定為bcl6的相互作用共壓子,bcl6是一種POZ/鋅指轉錄抑制因子,是生發中心形成所必需的,可能影響細胞凋亡。這種蛋白選擇性地與bcl6的poz結構域相互作用,但不與其他8種poz蛋白相互作用。特定的I類和II類組蛋白脫乙酰基酶(hdacs)與這種蛋白相互作用,這表明這兩類hdacs之間可能存在聯系。一些轉錄變體編碼不同的亞型已被發現的這個基因。在Y染色體上發現一個假基因。
    The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.

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  • 1v3多肉多车高校生活的玩视频