這個基因編碼一個鋅指蛋白Kruppel家族的成員。編碼的轉錄因子被聲波刺猬信號轉導級聯激活并調節干細胞增殖。這種蛋白的活性和核定位在抑制環中被p53負調控。已發現編碼該基因不同亞型的多種轉錄變體。
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.