CpG甲基化是一種表觀遺傳修飾，對胚胎發育、印記和X染色體失活具有重要意義。對小鼠的研究表明，DNA甲基化是哺乳動物發育所必需的。這個基因編碼一種DNA甲基轉移酶，被認為在從頭甲基化中起作用，而不是維持甲基化。該蛋白定位于細胞質和細胞核，其表達受發育調節。
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.