核孔復合體是一個巨大的結構，它橫跨核膜，形成一個通道，調節大分子在細胞核和細胞質之間的流動。核孔蛋白是真核細胞核孔復合體的主要成分。該基因編碼一種核孔蛋白，定位于孔籃和孔中央門控通道的核入口。編碼蛋白是caspase半胱氨酸蛋白酶的一個靶點，在細胞凋亡的程序性死亡中起中心作用。選擇性剪接導致編碼不同亞型的多個轉錄變體。[由RefSeq提供，2016年12月]
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]