RegulationofSplicingthroughSam68
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional regulation of splicing, RNA stability, and translation are also regulated by extracellular signals. Sam68, a member of a family of RNA-binding proteins called STAR proteins, mediates alternative splicing in response to extracellular signals, such as altered splicing of CD4......閱讀全文
Regulation－of－Splicing－through－Sam68
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
Regulation－of－MAP－Kinase－Pathways－Through－Dual－Specificity－Phosphatases
Mitogen-activated protein (MAP) kinases are important players in signal transduction pathways activated by a range of stimuli and mediate a number of
Regulation－of－hematopoiesis－by－cytokines
The process of hematopoesis is regulated by various cytokines. The comb
Regulation－of－BAD－phosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites re
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Gene－splicing－and－mutagenesis－by－PCRdriven－overlap－extension
實驗概要? ? ? ? Extension of overlapping gene segments by PCR is a simple, versatile technique for site-directed mutagenesis and gene splicing.Initial
Polyadenylation－of－mRNA
Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, trans
Cyclins－and－Cell－Cycle－Regulation
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins whi
CDK－Regulation－of－DNA－Replication
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to re
Regulation－of－eIF2
Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi
Regulation－of－PGC1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
GProtein－Signaling－Through－Tubby－Proteins
The tubby gene product is expressed in the brain and has been implicated by mouse genetics in obesity and other disorders such as blindness. Structura
Activation－of－PKC－through－G－protein－coupled－receptor
G-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common si
Signal－transduction－through－IL1R
Interleukin-1 (IL-1) is a pro-inflammatory cytokine that signals primarily through the type 1 IL-1 receptor (IL-1R1). The activities of IL-1 include i
Erythropoietin－mediated－neuroprotection－through－NFkB
Erythropoietin (Epo) is most commonly known as the cytokine secreted by the kidneys that stimulates red blood cell production and is used as a drug fo
TOP3A基因編碼的功能和結構描述
這個基因編碼一種dna拓撲異構酶，一種在轉錄過程中控制和改變dna拓撲異構酶狀態的酶。這種酶能催化單鏈dna的瞬時斷裂和重新連接，從而使單鏈dna彼此穿過，從而減少超螺旋的數量并改變dna的拓撲結構。這種酶與blm形成復合物，在體細胞重組中起調節作用。選擇性剪接導致編碼不同亞型的多個轉錄變體。Thi
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
FXR－and－LXR－Regulation－of－Cholesterol－Metabolism
Cholesterol is essential for life and a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol
Sprouty－regulation－of－tyrosine－kinase－signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
YBX1基因編碼的功能和結構描述
該基因編碼一種高度保守的冷休克蛋白，具有廣泛的核酸結合特性。編碼蛋白作為一種dna和rna結合蛋白，參與多種細胞過程，包括轉錄和翻譯調控、mrna前剪接、dna修復和mrna包裝。該蛋白也是信使核糖核蛋白（mrnp）復合物的組成部分，可能在microrna加工中起作用。這種蛋白可以通過非經典途徑分泌
TOP3A基因突變因子與藥物介紹
這個基因編碼一種dna拓撲異構酶，一種在轉錄過程中控制和改變dna拓撲異構酶狀態的酶。這種酶能催化單鏈dna的瞬時斷裂和重新連接，從而使單鏈dna彼此穿過，從而減少超螺旋的數量并改變dna的拓撲結構。這種酶與blm形成復合物，在體細胞重組中起調節作用。選擇性剪接導致編碼不同亞型的多個轉錄變體。[由R
YBX1基因突變因子與藥物介紹
該基因編碼一種高度保守的冷休克蛋白，具有廣泛的核酸結合特性。編碼蛋白作為一種dna和rna結合蛋白，參與多種細胞過程，包括轉錄和翻譯調控、mrna前剪接、dna修復和mrna包裝。該蛋白也是信使核糖核蛋白（mrnp）復合物的組成部分，可能在microrna加工中起作用。這種蛋白可以通過非經典途徑分泌
Signal－Dependent－Regulation－of－Myogenesis－by－Corepressor－MITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/M
Transcription－Regulation－by－Methyltransferase－of－CARM1
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Role－of－nicotinic－acetylcholine－receptors－in－the－regulation－of－apoptosis
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
BTG－family－proteins－and－cell－cycle－regulation
BTG2 is found to be one of the immediate early genes up-regulated by neural growth factor (NGF) and epidermal growth factor (EGF). Its transcriptional