該基因廣泛表達，參與多種不同轉錄因子的轉錄共激活。首先作為一種結合cAMP反應元件結合蛋白（creb）的核蛋白被分離出來，該基因通過將染色質重塑與轉錄因子識別結合，在胚胎發育、生長控制和體內平衡中發揮關鍵作用。該基因編碼的蛋白質具有固有的組蛋白乙酰轉移酶活性，也作為支架穩定與轉錄復合物的額外蛋白質相互作用。這種蛋白乙酰化組蛋白和非組蛋白。該蛋白在其溴域、富含半胱氨酸組氨酸區域和組蛋白乙酰轉移酶區域與p300蛋白具有很高的序列相似性。這種基因的突變導致魯賓斯坦-泰比綜合征（RTS）。涉及該基因的染色體易位與急性髓性白血病有關。選擇性剪接導致編碼不同亞型的多個轉錄變體。
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.