這個基因編碼一個重要的真核細胞翻譯起始因子。這種蛋白是43S復合體（一個40S亞單位，eif2/gtp/met-trnai和eif3）與帽狀RNA 5'端結合所必需的。
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.