這個基因編碼蛋白質elongin C，它是轉錄因子B（SIII）復合物的一個亞單位SIII復合物由elongins A/A2、B和C組成，它通過抑制RNA聚合酶II在轉錄單位內的許多位點上的短暫停頓來激活伸長elongin a作為siii復合物的轉錄活性成分發揮作用，而elongin b和c是調節亞單位。Elongin A2在睪丸中特異表達，能與elongins B和C形成穩定的復合物。von Hippel-Lindau抑癌蛋白與elongins B和C結合，從而抑制轉錄延長已鑒定出編碼兩種不同亞型的多個選擇性剪接轉錄變體[由RefSeq提供，2011年3月]
This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]