該基因屬于轉錄因子的叉頭家族，具有獨特的叉頭結構域。該基因可能通過表達細胞死亡所需的基因來觸發細胞凋亡。該基因與MLL基因易位與繼發性急性白血病有關。另外，還觀察到編碼相同蛋白質的剪接轉錄變體。
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.