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  • 發布時間:2022-08-15 17:33 原文鏈接: HCK基因編碼功能及結構描述

    這個基因編碼的蛋白質是酪氨酸激酶src家族的成員。這種蛋白質主要是造血的,特別是在髓系和B淋巴細胞系的細胞中。它可能有助于將fc受體與呼吸爆發的激活結合起來。此外,它可能在中性粒細胞遷移和中性粒細胞脫顆粒中發揮作用。由于選擇性剪接和選擇性翻譯起始密碼子(包括非aug密碼子)的使用,產生了具有不同亞細胞分布的多個亞型。[由RefSeq提供,2010年2月]
    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

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