TCL1基因在人類中的過度表達與成熟T細胞白血病的發生有關，其中染色體重排使TCL1基因接近T細胞抗原受體（TCR）-α（MIM 186880）或TCRβ（MIM 186930）調節元件（由VygILIO等，1998 [PubMed 9520462 ]概括）。在正常T細胞中，TCL1在CD4-/CD8-細胞中表達，但在分化后期細胞中不表達TCL1作為細胞存活激酶AKT（MIM 164730）的輔活化子（Laine等人，2000年[出版編號10983986]）。
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).