該基因編碼孕激素誘導蛋白，屬于HECT（與E6-AP羧基末端同源）家族hect家族蛋白作為e3泛素蛋白連接酶發揮作用，靶向泛素介導的蛋白水解的特異性蛋白。該基因定位于染色體8q22，在多種癌癥中被破壞。這個基因可能在細胞增殖或分化的調節中起作用[由RefSeq提供，2008年7月]
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]