這個基因編碼腦膜,一種與多發性內分泌腫瘤1型綜合征相關的假定的腫瘤抑制因子。體外研究表明,腦膜定位于細胞核,具有兩種功能性核定位信號,并通過JUND抑制轉錄激活,但這種蛋白的功能尚不清楚。在Northern blots上檢測到兩條信息,但未對較大的信息進行描述。選擇性剪接導致多個轉錄變體。
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.