該基因編碼雌激素受體家族和核受體轉錄因子超家族中的一員。該基因產物包含一個n端dna結合域和c端配體結合域，定位于細胞核、細胞質和線粒體。在與17β-雌二醇或相關配體結合后，編碼的蛋白質形成與特定DNA序列相互作用的同源或異源二聚體以激活轉錄。某些亞型主要抑制其他雌激素受體家族成員的活性。已經描述了該基因的幾個選擇性剪接的轉錄變體，但其中一些變體的全長性質尚未完全描述。[由RefSeq提供，2008年7月]
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]