該基因編碼葉酸聚谷氨酸合成酶這種酶在建立和維持細胞液和線粒體的葉酸多聚谷氨酸濃度方面起著中心作用，因此，對于葉酸的穩態和增殖細胞的生存至關重要這種酶催化谷氨酸部分對葉酸和葉酸衍生物的ATP依賴性加成選擇性剪接導致編碼不同亞型的轉錄變體。[由RefSeq提供，2014年1月]
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]