該基因編碼的蛋白屬于磷脂酰肌醇3，4，5-三磷酸（PIP3）依賴性rac交換子（prex）家族，是rac家族小G蛋白的DBL型鳥嘌呤核苷酸交換因子。該蛋白的結構域包括催化彌漫性B細胞淋巴瘤同源性和普雷克星同源性（DHPH）域、兩個不齊的EGL-10和普雷克星同源性（DEP）域、兩個PDZ域和一個在其中一個亞型中發現的C端肌醇多磷酸-4磷酸酶（IP4P）域。這種蛋白促進了在rac1上的gdp與gtp的交換，允許gtp結合的rac1激活下游效應器。研究還表明，該蛋白的Pleckstrin同源域與磷酸酶和緊張素同源（PTEN）基因產物相互作用，抑制PTEN磷酸酶活性，從而激活磷酸肌醇-3激酶（PI3K）信號通路。相反，PTEN基因產物也被證明能抑制這種蛋白的GEF活性。該基因在胰島素信號傳導途徑中起作用，在一些癌癥中觀察到該基因的突變或過度表達。
The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.