總結
活體多光譜熒光成像可以扣除組織自體熒光和進行多種熒光團成像。這可以增強信噪比并進行先進的多重熒光成像，實現更強大的研究設計。 參考文獻 [1] Levenson RM, Lynch DT, Kobayashi H, Backer JM, Backer MV (2008). Multiplexing with multispectral imaging: from mice to microscopy. ILAR J 49-78. [2] Frangioni, JV (2003). In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol.;7:626-34. [3] Weissleder R, Ntziachristos V (2003). Shedding light onto live molecular targets. Nat Med. 9( 1 ) 123-8. [4] Farkas DL, Du C, Fisher GW, Lau C, Niu W, Wachman ES, Levenson RM (1998). Non-invasive image acquisition and advanced processing in optical bioimaging. Comput Med Imaging Graph. 22(2):89-102. [5] Alexander L, Dhaliwal K, Simpson J, Bradley M. (2008) Dunking doughnuts into cells--selective cellular translocation and in vivo analysis of polymeric micro-doughnuts. Chem Commun (Camb). 14;( 30 ):3507-9 [6] Chou LY, Chan WC (2012). Fluorescence-tagged gold nanoparticles for rapidly characterizing the size-dependent biodistribution in tumor models. Unpublished.
