WIKI資訊
Presenilin-1 (PS1) is associated with gamma secretase activity that cleaves amyloid precursor protein (APP) and is implicated in Alzheimer's disease. Presenilin-1 is also a component in gamma-secretase activity involved in signaling by the transmembrane protein Notch. Active gamma secretase requires PS-1 N-terminal fragment and a C-terminal fragment and is unique in catalyzing proteolysis within the transm......閱讀全文
Notch is a large cell-surface receptor that is activated by contact with membrane-bound ligands on neighboring cells. The ligands that activate Notch
In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation
Alzheimer's disease is associated with dense aggregations of proteins in the brain called amyloid plaques that contain beta-amyloid fragments as a
2018年5月份即將結束了，5月份Science期刊又有哪些亮點研究值得學習呢？小編對此進行了整理，與各位分享。 1.Science：腸道微生物組竟能控制肝臟中的抗腫瘤免疫反應 doi:10.1126/science.aan5931； doi:10.1126/science.aat8289
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
Abstract Choriallantoic membrane (CAM) limb grafting functions as a method to isolate the inductive eve
Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in a
Hepatitis B is a small DNA virus that contains only 4 open reading frames in its genome. Three of these ORFs have been identified as the envelope, cap
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
截至2019年12月23日，中國學者在Cell，Nature及Science在線發表了107篇文章（2019年的Cell ，Nature 及Science 已經全部更新），iNature團隊對于這些文章做了系統的總結： 按雜志來劃分：Cell 發表了31篇，Nature 發表了44篇，Scie
2019年上半年很快就結束了，iNature盤點了中國學者在Cell，Nature及Science發表的成果，我們發現總共有86篇（截至2019年6月24日），具體介紹如下： 4-6月發表的文章 【1】2019年6月21日，西北工業大學王文，中科院昆明動物研究所/BGI 張國捷及丹麥哥本哈根
Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated t
截至2019年12月31日，中國學者在Cell，Nature及Science在線發表了186篇文章，其中生命科學領域有109篇，材料學有30篇，物理學有20篇，化學有12篇，地球科學有15篇。iNature團隊對于這些文章做了系統的總結： 按雜志來劃分：Cell 發表了31篇，Nature 發
截至2019年12月13日，中國學者在Cell，Nature及Science在線發表了105篇文章（2019年的Cell已經全部更新完畢，而對于Nature及Science只剩下了一期，將分別會12月19日及20日進行更新），小編對于這些文章做了系統的總結： 按雜志來劃分：Cell 發表了30
AbstractPrevious studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos r
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
1】Oncology Letters：大豆卵磷脂與非甾體抗炎藥組合可預防癌癥且副作用更小！ doi：10.3892/ol.2018.8098 當德克薩斯大學健康醫學中心（UTHealth）的科學家將大豆卵磷脂和一種非甾類抗炎藥（NSAID）一起應用時，他們發現其抗癌性增加且副作用減輕了。這一
在免疫學實驗中，比如WB，IHC，IF等，大家都知道選著好正確的一抗，往往實驗就成功了一大半，因此，往往很多研究者便會忽視對二抗，以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品，包裝大，因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話，影響的可能就是一整個實驗室或者課題組了。艾美
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response
Our experience indicates that it may not be sufficient to change the medium containing Rottlerin and to wash the cells before adding MTT to avoid a po
Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation.
Lipoprotein Analysis Week 2: Electrophoresis IntroductionSDS polyacrylamide gel electrophoresis (SDS PAGE) will be used to assess the
Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of si
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
《Cell Stem Cell》雜志是2007年Cell出版社新增兩名新成員之一（另外一個雜志是Cell Host & Microbe），這一雜志內容涵蓋了從最基本的細胞和發育機制到醫療軟件臨床應用等整個干細胞生物學研究內容。這一雜志特別關注胚胎干細胞、組織特異性和癌癥干細胞的最新成果。
自中科院上海生命科學研究院生物化學與細胞生物學研究所，干細胞生物重點實驗室（Key Laboratory of Stem Cell Biology），日本福井大學（Fukui University）醫學院，美國Sloan-Kettering癌癥研究中心（Memorial Sloan-Ketterin
Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria i