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Heart formation is cued by a combination of positive and negative signals from surrounding tissues. Inhibitory signals that block heart formation in anterior paraxial mesoderm include Wnt family members expressed in dorsal neural tube and anti-BMPs expressed in the axial tissues (i.e., noggin in the notochord). Wnt signalling pathway, which is essential for setting up the entire body pattern during embryonic developm......閱讀全文
Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with incr
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis 【摘要】&nb
FIG. 4.Aberrant gene expression patterns of cardiac remodeling factors in ARKO male mice with or without Ang II stimulation. The left panel demons
Homeodomain transcription factors comprise a large family of DNA binding factors that regulate transcription and development. Many homeodomain genes a
One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickn
[摘要] 目的:探討心肌酶譜和肌鈣蛋白I聯合檢測在急性心肌梗死早期診斷的臨床應用價值。方法:對2009年1月～2010年1月本院就診的205例就診的急性胸痛患者同時聯合檢測心肌酶譜(AST、LDH、CK、CK-MB、HBDH、Mg2 )和肌鈣蛋白I(cTnI),比較其檢測結果對于診斷急性心肌梗死的特
Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can
背景介紹 1958年Sutherland發現了cAMP(環磷酸腺苷)，并因此獲得了1971年諾貝爾生理與醫學獎[1]. 1963年Ashman發現了cGMP（環磷酸鳥苷）[2]。50年過去了，人們已明白cAMP、cGMP是在很多生理過程中發揮重要調節作用的第二信使分子。鳥苷酸環
1. Ventricles were removed under sterile conditions. 2. Ventricles were placed in cold sterile primary cell culture medium, minced into
Sphingosine-1-phosphate (S1P) is an example of lipid messengers with both intracellular and extracellular functions. Intracellularly S1P regulates pro
Ang II-stimulated Cardiac Dysfunction in ARKO Male Mice-We also evaluated the cardiac performance of these mice using echocardiography. Although l
TABLE IPrimer sequences for mRNA analyses Sequences are listed 5' to 3'.Quantitative Real-time PCR by SYBR Green Detection Method-The mRNA l
在免疫學實驗中，比如WB，IHC，IF等，大家都知道選著好正確的一抗，往往實驗就成功了一大半，因此，往往很多研究者便會忽視對二抗，以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品，包裝大，因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話，影響的可能就是一整個實驗室或者課題組了。艾美
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
[摘要] 目的：探討血漿B型鈉尿肽水平對急性心肌梗死患者心功能預測價值。方法：收集86例急性心肌梗死患者，心梗后6 h內抽血檢驗血漿B型鈉尿肽水平及評估患者心功能，同時收集40例健康者做為對照組；隨訪3個月后，比較急性心肌梗死左室射血分數<50%和>50%兩組患者血漿B型鈉尿肽水平；同時
ThermoregulationAnimals frequently become hypothermic during anesthesia because of inhalation of cold gases, exposure of body cavities to the room air
Intraperitoneal:Equipment: Syringe and 23 to 27 g, 1/2 to 1-inch needle, preferably with a short bevel.Volume: The volume injected IP into a
Anesthetic MachineThe best method of delivering an inhalant anesthetic is with an anesthetic machine. These machines precisely mix the gas
背景：腎素-血管緊張素-醛固酮系統可通過多種病理條件來影響心臟細胞形態和功能。本研究揭示醛固酮對心肌細胞表達縫隙連接蛋白Cx43的影響。 方法與結果：培養好的乳鼠期大鼠心肌細胞暴露于醛固酮24小時，檢測Cx43蛋白和mRNA表達量。通過多電極陣列系統（Med-64）檢測刺激全過程。用10-8mol/
Other AnalgesicsAnalgesics are pain relievers most often given after a surgery. Narcotic analgesics have already been described above. Nonsteroid
Selection Of Anaesthetic Drugs: Halothane, Isoflurane Or Sevoflurane吸入麻醉藥的選擇：氟烷、異氟烷、七氟烷Speed of Induction and Recovery誘導與蘇醒速度Sevoflurane is half as so
Bryce Olson是英特爾的一名員工，幾年前，非常突然的，Bryce被診斷出了IV期前列腺癌，腫瘤的侵襲性很強，而且已經發生了多處轉移。一開始，Bryce嘗試了手術、化療和放療，然而這些傳統療法都不能阻止腫瘤的發展。Bryce想，按照這樣發展，自己大概看不到女兒小學畢業了。 傳統療法的大門
每年的美國臨床腫瘤學會年會就像一個超級“嘉年華”，層出不窮新研究、新熱點、新觀點、新“明星”（藥）令人眼花繚亂。如何能有條不紊地即能抓住重點，又能兼顧熱點，大概是每位即將親身經歷或者隔空關注年會的醫生的“心事”。為此，記者特別邀請中國臨床腫瘤學會（CSCO）理事長、廣東省人民醫院吳一龍教授，為讀
眾所周知，2017 諾貝爾生理或醫學獎頒發給了三位美國遺傳學家杰弗里·霍爾（Jeffrey C. Hall）、邁克爾·羅斯巴什（Michael Rosbash），以及邁克爾·楊（Michael W. Young），以表彰他們在發現果蠅生物節律分子機制方面的貢獻。而在此前，醫學界真正將生物節律——
In an attempt to be concise and understandable, introductory level courses and textbooks frequently present concepts that are technically correc
Mitochondria Structure and Function - Theoretical DetailsIn an attempt to be concise and understandable, introductory level courses and textbooks freq
Administration of Fluids and Drugs (Overview):Gastro-Intestinal Tract:Oral or per os (po)- - through the mouthGavage - - into the stomach vi
The cytoplasm of nearly all eukaryotic cells contain mitochondria, although there is at least one exception, the protist Chaos (Pelomyxa) carolin
作者：劉鳳珍，邢家林，柳薇，龔慶成 【摘要】 目的 觀察體外循環預充的庫存懸浮紅細胞(懸紅)經超濾后電解質及生化指標的變化。方法 將作為小嬰兒預充的懸紅2個單位為1份，共選30份懸紅，入選懸紅存放日期為5～13 d。30份懸紅超濾前為A組(n=30)，超濾后為B組(n=30)，