References1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a cancer journal for clinicians. 2015; 65: 87-108.2. Hall-Craggs MA, Vaidya JS. Minimally invasive therapy for the treatment of breast tumours. European journal of radiology. 2002; 42: 52-7.3. Vogl TJ, Farshid P, Naguib NN, Zangos S. Thermal ablation therapies in patients with breast cancer li......閱讀全文
Interleukin-6 Induced Acute Phenotypic Microenvironment Promotes Th1 Anti-Tumor ImmunityTing Xue1, Ping Liu1, Yong Zhou2, Kun Liu1, Li Yang2, Robert L
In this study, we found that “acute” response was strongly induced by cryo-thermal therapy with “acute” and high expression of a series of acute p
Cryo-thermal therapy induced an “acute” phase response First, we performed PRM analysis upon significant proteins involved in acute phase respo
ConclusionIn summary, using comprehensive discovery proteomics analysis followed by target proteomics validation at a large scale sample size, we
在免疫學實驗中,比如WB,IHC,IF等,大家都知道選著好正確的一抗,往往實驗就成功了一大半,因此,往往很多研究者便會忽視對二抗,以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品,包裝大,因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話,影響的可能就是一整個實驗室或者課題組了。艾美
As a primary component of circulatory system, serum is the major reservoir of thousands of proteins secreted or “leaked” from a broad spectrum of
【摘要】 血清淀粉酶的測定仍是診斷急性胰腺炎的最常用的生化標志物。但就診較晚,高甘油三酯血癥和慢性酒精中毒患者的血清淀粉酶的敏感性降低。尿胰蛋白酶原-2是個合適的、有較高診斷準確性的生化標志物。重癥急性胰腺炎在發病48h內通過有效的評分系統可早期診斷,但新的血清生化標志物,如降鈣素原和IL-6在急性
IntroductionFetal Alcohol Syndrome (FAS) is caused by exposure of the developing embryo to alcohol, one of several teratogenic agents which adversely
Results Enterotoxin Induced Histamine and LTC4 Release. Basophils from healthy subjects did not release more than 2 % histamine to any staphy
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
The strongest and unique “acute” environment induced by cryo-thermal therapy stimulated the most effective anti-tumor immune response As desc
In summary, we suggested that “acute” response could elicit innate and Th1 adaptive immunity, reversing the tumor-mediated immunosuppressive envir
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
AbstractPrevious studies by Stachel and colleagues indicate that lithium chloride induction of post-midblastular Brachydanio rerio embryos r
摘要:目的 研究中藥藥對虎杖-桂枝對急性痛風性關節炎的影響。方法 取雄性 SD 大鼠 48 只,隨機分為 6組(每組 8 只),即正常對照組,模型組,秋水仙堿組(0.1 g·kg-)1,虎杖-桂枝低、中、高劑量組(3.5,7,14 g·kg-)1。正常對照組和模型組給予等量生理鹽水,其他各組給予相
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
摘要:目的 研究中藥藥對虎杖-桂枝對急性痛風性關節炎的影響。方法 取雄性 SD 大鼠 48 只,隨機分為 6組(每組 8 只),即正常對照組,模型組,秋水仙堿組(0.1 g·kg-)1,虎杖-桂枝低、中、高劑量組(3.5,7,14 g·kg-)1。正常對照組和模型組給予等量生理鹽水,其他各組給予
摘要:目的 研究中藥藥對虎杖-桂枝對急性痛風性關節炎的影響。方法 取雄性 SD 大鼠 48 只,隨機分為 6組(每組 8 只),即正常對照組,模型組,秋水仙堿組(0.1 g·kg-)1,虎杖-桂枝低、中、高劑量組(3.5,7,14 g·kg-)1。正常對照組和模型組給予等量生理鹽水,其他各組給予
動物術中和術后保溫是動物實驗過程中的一個至關重要的環節,是否做好保溫措施直接關系到實驗的成敗,同時也是科研工作者在進行生命科學相關研究中將實驗動物倫理和福利付諸實踐的真正體現,是對動物愛心的社會責任感的體現。善待活著的動物,減少動物死亡的痛苦!動物手術保溫的科學價值Responsible scien
環孢素A(cyclosporin A,CsA)是一種強效免疫抑制劑,廣泛應用于器官移植后抗排斥,及自身免疫性疾病的治療。CsA誘導的牙齦肥大(CsA induced gingivalo vergrowth,CIGO)屬于藥物性牙齦增生(drug induced gingival overgrow
Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the
張新超 北京醫院急診科 在臨床實踐中,沒有哪個器官系統病癥像心血管疾病在救治時效性方面的意義更為突出。急性心肌梗死(acute myocardial infarction,AMI)后1 h內得到再灌注治療,死亡率為1%,6 h內得到治療,死亡率約為10%~12%
Ambion and Applied Biosystems have joined forces to provide a complete convenient, solution for performing gene silencing experiments and validating t
Circulating bone marrow (BM)–derived endothelial progenitor cells (EPCs) are recruited to the site of tissue regeneration and substantially contri
生物分子發表的代表性文獻 QTRAP:同時具有三重四極桿和線性離子阱性能的獨一無二的LC/MS/MS系統 QTRAP系統最早在ASMS 2002上,作為第一臺商用的線性離子阱發布,是世界上唯一的線性離子阱和三重四極桿的復合
Target analysis by Parallel reaction monitoring (PRM)The targeted quantification and verification were carried out in 94 serum samples with 5~
血糖監測是糖尿病管理的重要內容。已有多項大型臨床研究證實,糖化血紅蛋白(HbA1c)與糖尿病慢性并發癥的發生存在關聯,將HbA1c水平控制在合適的范圍內可以有效降低慢性并發癥的風險,因此,長久以來HbA1c一直被視作評價糖尿病患者長期血糖控制狀況的金標準[1]。然而,血紅蛋白的更新速度異常,某些情況
昨日,美國FDA批準了全球第二個CAR-T上市,用于治療特定非霍奇金淋巴瘤,這是繼諾華的首個CAR-T療法的又一次重大突破。腫瘤免疫療法頻傳捷報,特別是以嵌合抗原受體T細胞技術(CAR-T)以及免疫檢查點阻斷技術為代表的新興腫瘤免疫療法,發揮著巨大潛力。考慮到該療法臨床前評估需要接近人類免疫系統且具
為了跟前文“關節炎中軟骨破壞方向的細胞模型”相對應,這里標題還用了“關節炎”這個描述,但其實,關節炎中涉及滑膜炎癥的主要是類風濕關節炎(rheumatoid arthritis,RA)。也是關節炎中研究最廣泛的類型之一。在類風濕關節炎發病進展中,至少涉及三大類細胞,免疫細胞,骨細胞,滑膜細胞。免疫細
隨著人類基因組計劃(human genome project )在2003年順利完成,基因組測序技術取得了長足的進步,這直接導致了每兆基因組成本的大幅下降以及檢測的基因組數量越來越多。人們對基因組的復雜性深感震驚,這也引導著測序技術的進一步發展。最近的一些突破性技術使得測序技術在更短的時間內可以