MechanismsoftranscriptionalrepressionbyDNAmethylation
Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA methylation events, are frequently involved in transcriptional changes in both tumor suppressor genes and oncogenes. Methylation of cytosine at CpG dinucleotides is a common feature of a higher eukaryotic genomes. DNA methylation in the promoter regions of genes is gener......閱讀全文
Mechanisms of transcriptional repression by DNA methylation
Tumorigenesis is known to be a multistep process in which defects in various cancer genes accumulate. Epigenetic modifications, most importantly DNA m
Repression of Pain Sensation by the Transcriptional Regulator DREAM
The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain s
Sumoylation by RanBP2 Regulates Transcriptional Repression
Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation.
Overview of telomerase RNA component gene hTerc Transcriptional Regulation
Telomerase is an enzyme which replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells which have an unlimited replica
Basic Mechanisms of SUMOylation
Like ubiquitin, SUMO (small ubiquitin-related modifier) proteins are small protein tags that are conjugated to proteins to modify their function. The
The PRC2 Complex Sets Long 杢erm Gene Silencing Through Modification
Packaging of DNA into chromatin allows the cell to store its genetic information efficiently and has an important role in regulating gene expression.
Protein arginine methylation
Typical modification sites: RGG box or RXR sequence motifs R-arginine, G-glycine, X-any aminoacid. Enzymes catalysing protein arginine methylation: P
Methylation Specific PCR
Methylation Specific PCRProtocol written by James Herman*Methylation Specific PCR (MSP) is a simple rapid and inexpensive method to determine the meth
The information-processing pathway at the IFN-beta enhancer
The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication and
SETDB1基因編碼的功能和結構描述
這個基因編碼一個組蛋白甲基轉移酶，它調節組蛋白甲基化、基因沉默和轉錄抑制。鑒于基因沉默和轉錄功能障礙可能在亨廷頓病的發病機制中起作用，該基因已被確定為亨廷頓病治療的靶點已經描述了該基因的選擇性剪接轉錄變體。This gene encodes a histone methyltransferase w