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Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells such as formation of epithelial cell layers. E-cadherin inactivation has b......閱讀全文
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
Scanning the human genome with combinatorial transcription factor librariesPublished online: 18 February 2003, doi:10.1038/nbt794March 2003 Volume 21
ConclusionsQuorum-sensing signaling systems involving the interaction between a signaling peptide and its cognate histidine kinase receptor are widely
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
Carbohydrate Assay (Hancock Laboratory) (Accessible only by IE)This protocol is used to determine the relative amounts of LPS CHO present in a gi
The G-protein coupled receptor (GPCR) family transduces extracellular signals across the plasma membrane, activating cellular responses through a vari
Sonic Hedgehog (Shh) is one of a family of three secreted proteins, including Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), that play distinct and
BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the ce
Rac-1 is a small G-protein in the Rho family that regulates cell motility in response to extracellular signals. Several changes in cytoskeletal struct
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T
IntroductionFetal Alcohol Syndrome (FAS) is caused by exposure of the developing embryo to alcohol, one of several teratogenic agents which adversely
Bead-array-based microRNA detection technology, including the bio-statistic analysis, is currently not well established or widely used and we have app
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
實驗概要Central neurons lose the ability for axonal regrowth during development and typically do not regenerate their axons following axotomy once the
CSP-Dependent Transformation AssayTo determine if synthetic peptides activated quorum sensing for induction of genetic competence, we used the co
Interaction of T cell receptor with specific antigen in the context of MHC II activates a signal transduction pathway that leads to T cell activation.
獲得性免疫具有記憶效應。免疫系統在感染之后發展出的長期記憶T細胞可以應對未來感染。這些記憶T細胞具有干細胞性質。最近研究已經證實了在慢性感染中耗竭性CD8+ T細胞中，存在著一種獨特的干細胞樣的T細胞亞群【1】。然而，在慢性感染情況下，CD4+ T細胞是否也有類似性質的亞群仍不清楚。TH17細胞
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
Abstract Choriallantoic membrane (CAM) limb grafting functions as a method to isolate the inductive eve
ObjectiveThe purpose of this experiment is to determine the effects of calcium-free seawater on the development of sea urchin embryos. Embryos were pl
MTT Assay on Reattached CellsAs seen in Fig. 2 , the proportion of viable MSC that re-attached was significantly higher (p?
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
GREATER GENEVA BERNE area (GGBa) GREATER GENEVA BERNE area (GGBa) is an Economic Development Agency complementary to BioAlps ‘s mission offerin
Many transcription factors play essential roles in normal development by determining the proliferation and differentiation of cells. The coordinated t
Our experience indicates that it may not be sufficient to change the medium containing Rottlerin and to wash the cells before adding MTT to avoid a po
引言：上海吉凱基因化學技術有限公司成立于2002年，擁有國內最大的慢病毒文庫，同時也是國內最大的疾病關鍵基因科研服務供應商，在疾病研究領域的實驗積累已逾14年！在這里，我們為大家特別整理了10多個研究領域的經驗所得，將最實用的精華分享給大家！上一期幫大家總結了肺癌研究中慢病毒工具的應用，上期回顧看這
Cytokine BioassaysIntroductionBiological activity of cytokines and their concentrations are commonly measured by cellular proliferation of primary cel
Sonic Hedgehog (Shh) is a secreted protein identified genetically as an important developmental factor. Shh provides a morphogenic signal in the devel
截止2020月7月27日，中國學者在Cell，Nature 及Science 發表了共計102項生命科學的研究成果，其中新冠肺炎領域占了近一半（共43篇）。iNature系統總結了這些研究成果： 按雜志來劃分：Cell 發表了30篇，Nature 發表了45篇，