Rolesof？arrestindependentRecruitmentofSrcKinasesinGPCRSignaling

The binding of ?-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor—?-arrestin complex. Several signaling events have been reported to involve ?-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent ?2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by ?2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation

Contributor: Kosi Gramatikoff, PhD

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