Pelp1ModulationofEstrogenReceptorActivity
Proline-,glutamic acid-,leucine-rich protein 1 (Pelp1 also known as:modulator of nongenomic activity of estrogen or MNAR) is a recently discovered transmitter of estrogen signals. The receptors for estrogen (ER), progestin (PR), androgen (AR) and others are steroid hormone receptors, which are part of a large family of ligand-inducible transcription factors. It has been established that estrogen has at least two cour......閱讀全文
Pelp1 Modulation of Estrogen Receptor Activity
Proline-,glutamic acid-,leucine-rich protein 1 (Pelp1 also known as:modulator of nongenomic activity of estrogen or MNAR) is a recently discovered tra
CARM1 and Regulation of the Estrogen Receptor
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Bone Remodelling
Bone density and structure is maintained through a balance of bone resorption by osteoclasts and bone deposition by osteoblasts. The combination of si
Regulation of PGC-1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
ESR2基因突變與藥物因子介紹
該基因編碼雌激素受體家族和核受體轉錄因子超家族中的一員。該基因產物包含一個n端dna結合域和c端配體結合域，定位于細胞核、細胞質和線粒體。在與17β-雌二醇或相關配體結合后，編碼的蛋白質形成與特定DNA序列相互作用的同源或異源二聚體以激活轉錄。某些亞型主要抑制其他雌激素受體家族成員的活性。已經描述了
ESR2基因編碼功能及結構描述
該基因編碼雌激素受體家族和核受體轉錄因子超家族中的一員。該基因產物包含一個n端dna結合域和c端配體結合域，定位于細胞核、細胞質和線粒體。在與17β-雌二醇或相關配體結合后，編碼的蛋白質形成與特定DNA序列相互作用的同源或異源二聚體以激活轉錄。某些亞型主要抑制其他雌激素受體家族成員的活性。已經描述了
Induction of apoptosis through DR3 and DR4/5 Death Receptors
Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3
Assay of Phospholipase A Activity
Phospholipases of the A type constitute a large family of esterases that catalyze the hydrolysis of the fatty acid ester bonds in phospholipids a
Inactivation of Gsk3 by AKT causes accumulation of b-catenin
Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria i
Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor
The neuregulins comprise a subfamily of at least four epidermal growth factor (EGF)-like growth factors that influence a variety of cellular events, i