InhibitionofCellularProliferationbyGleevec
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. While traditional cytotoxic cancer treatments such as chemotherapy or radiation therapy kill all dividing cells, Gleevec acts on a molecular target by a mechanism that is more specific to cancer cells. Traditional cytotoxic cancer agents have serious side effects such as na......閱讀全文
Inhibition of Cellular Proliferation by Gleevec
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. Whil
Cadmium induces DNA synthesis and proliferation in macrophages
Exposure to divalent cadmium ions (Cd2+) is a known cancer risk factor, but the molecular mechanisms responsible for the in
ELISA Inhibition Assay
ELISA Inhibition AssaySensitize a 96-well microtiter plate with purified antigen.Prepare a solution of the purified antigen of interest in phosphate b
Inhibition of Matrix Metalloproteinases
Cellular transformation is accompanied by many cellular changes, including uncontrolled proliferation, loss of the differentiated cell morphology, and
cell proliferation assay
cell proliferation assaybefore start:thaw cells from liquid nitrogen, grow in 75cc flask (T75) in Fischer's medium MM (maintenance medium) until c
Sprouty regulation of tyrosine kinase signals
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
MTT Cell Proliferation Assay
MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, first described by Mosmann in 1983, is based on the ability of a mitochondri
Inhibition of the fast and slow blocks to polyspermy
Objective: to test the effects of inhibiting the fast and slow blocks to polyspermy on sea urchin development.BackgroundSea urchin eggs release compon
Inhibition of Huntington's disease neurodegeneration
Huntington's disease is a neurodegenerative condition caused by a dominant mutation in a gene encoding a protein now called huntingtin. Large poly
Cellular & Molecular Pathology Branch
Vision To provide scientific collaboration of excellence to National Toxicology Program (NTP)?(http://ntp.niehs.nih.gov/)?interdisciplinary research