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Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPAR-gamma is a member of this gene family that is activated by fatty acids and thiazolidinedione drugs that plays a role in insulin sensitivity and adipogenesis (See Visceral Fat Deposits and the Metabolic Syndrome pathway). Like PPAR-alpha and other members of this gene family, PPAR-gamma activ......閱讀全文
Obesity is associated with many adverse health effects, including an increased risk of diabetes and heart disease. The combined condition of obesity,
Perspectives Obesity is closely associated with hypertension. The mechanisms underlying hypertension in obesity, however, have not
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension作者：Koji Ohashi; Shinji Kihara; Noriyuki Ouchi; Masahiro Kumada; Koichi Fujita; Aki
Discussion The major findings of the present study were the following: (1) adiponectin supplementation reduced the SBP of sponta
一、飲食、能量攝取、肥胖與腸道菌群之間的關系：1. A core gut microbiome in obese and lean twins——2009《Nature》——if 36.102. An obesity-associated gut microbiome wit
The insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle wher
The vitamin D receptor, VDR is the mediator of all genomic actions of vitamin D3 and its analogs. It belongs to a family of ligand induced transcripti
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis 【摘要】&nb
The somatotropic axis. The synthesis and release of growth hormone (GH) from the pituitary are controlled by the hypothalamic hormones GH-releasing ho
Nuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine n
Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine
RNA的m6A修飾是RNA表觀遺傳學研究領域的大熱門，近年來相關研究多次登上高分雜志。從胚胎發育到疾病進程，從RNA的穩定性到可變剪接和翻譯效率，m6A的功能幾乎無處不在（圖1）。圖1 由于m6A是一種RNA修飾，若想知道它在某一體系（發育階段或癌癥）中的作用，目前大部分研究都是基于影響m6A
Results Adiponectin Supplementation Decreases Blood Pressure in Obese Diabetic KKAy Mice We studied genetically ob
The mean hemoglobin in group 1 was 9.9 mmol/L prior to the anesthesia and decreased to 8.7 mmol/L 10 min after administration of the an
實驗動物代謝監測系統（籠統地稱為代謝籠）選擇需要關注的問題目前，全球及中國糖尿病肥胖等代謝疾病的發病率越來越高，越來越需要我們認真去研究對待，因此對糖尿病肥胖等代謝疾病的研究越來越多。 該研究一般以大小鼠為實驗對象，通過大小鼠的呼吸商（即呼入氧氣和
幾十年來，DNA一直被認為是決定生命遺傳信息的核心物質，但是近些年不斷的研究表明，生命遺傳信息從來就不是基因所能完全決定的，比如科學家們發現，可以在不影響DNA序列的情況下改變基因組的修飾，這種改變不僅影響個體的發育，而且還可遺傳給后代。如腫瘤等多種疾病并非僅由基因突變而引起，且與DNA和組蛋白
2. 神經系統疾病▼ 致病機理：神經細胞中由于遺傳缺陷導致的疾病▼ 代表工作：同時另一項突破性的工作則使用一種SunTag（dCas9-10xGCN4）系統融合多個拷貝的轉錄激活蛋白（p65-HSF1），構建了一種Cre依賴性的SunTag-p
Sara Campbell告訴《科學家》網站，當她2010年第一次在PubMed上輸入“鍛煉（exercise）和微生物組（microbiome）”并按回車鍵時，搜索結果實際上是零。Campbell剛剛開始在美國羅格斯大學擔任運動科學助理教授。作為一名運動員，她在博士和博士后期間研究膽固醇代謝、
專題：Nature報道 本期封面所示為棕色脂肪，在其中，PRDM16的表達被shRNA抑制，肌肉細胞標記為紅色，脂肪細胞和其他細胞類型標記為藍色核。封面美術：Eric Smith。 人體中有兩種類型的脂肪組織：一種是棕色脂肪，主要功能是燃燒卡路里，產生身體所需熱量；另一種
ContentsEmbryonic Stem Cell MarkersHematopoietic Stem Cell MarkersMesenchymal/Stromal Stem Cell MarkersNeural Stem Cell MarkersReferencesWhile stem ce
FL3500雙調制葉綠素熒光儀 （新升級型號為FL6000） FL3500雙調制葉綠素熒光儀是專門用于對藍綠藻或綠藻等微藻，葉綠體或類囊體懸浮物，乃至葉片進行光合作用研究的強大科研工具。儀器具備雙通道測量控制，可控制測量樣品的溫度，并配備單翻轉光（STF），內置多種可用戶自行修改的測量程序
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
德國WALZ公司生產的M系列調制葉綠素熒光成像系統IMAGING-PAM，作為全球最權威的葉綠素熒光成像系統，在國際科研界得到了廣泛應用，已經成為葉綠素熒光成像研究的行業標準。 澤泉科技有限公司作為德國WALZ在中國的技術服務中心，一直以來致力于推廣調制葉綠素
FIG. 4.Aberrant gene expression patterns of cardiac remodeling factors in ARKO male mice with or without Ang II stimulation. The left panel demons
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
ObjectiveThe objective of the experiment is to determine the effects of ethanol exposure on the embryonic development of zebrafish through observation
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
John “JC” Carver, a payload integration engineer with NASA Kennedy Space Center’s Test and Operations Support Contract, uses a FluorPen to measure