WIKI資訊
Phosphorylation of SubstratesScott T. Eblen, N. Vinay Kumar, and Michael J. WeberDepartment of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, VA 22908Excerpted from Protein: Protein Interactions, Second EditionEdited by Erica A. Golemis and Peter D. AdamsABSTRACTIdeally, one would like to be able to directly phosphorylate substrates in an intact cell. This could potentiall......閱讀全文
實驗概要Ideally, one would like to be able to directly phosphorylate substrates in an intact cell. This could potentially be performed by intr
實驗概要 Small synthetic peptide substrates are especially well suited for applications such as assays of tyrosine kinases
Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads to
Protein kinase A regulatory subunit RIIalpha (PKA-RIIa) is tightly bound to centrosomal structures during interphase through interaction with the A-ki
Identification of a Mutant Kinase/ATP Analog PairScott T. Eblen, N. Vinay Kumar, and Michael J. WeberDepartment of Microbiology and Cancer Center, Uni
Screening Kinase Phosphorylation Motifs Using Peptide LibrariesIsaac A. Manke and Michael B. YaffeCenter for Cancer Research, Massachusetts Institute
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia. Whil
長時間的清醒會導致認知障礙，而睡眠能夠通過分子生物化學的改變來“刷新”大腦，這些變化影響著神經元的可塑性和大腦的功能。然而，多年來，“想睡覺”背后的分子基礎一直沒有被很好地理解。 目前關于睡眠-覺醒周期（sleep-wake cycle）的理論表明，覺醒編碼記憶，而睡眠則鞏固記憶并修復突觸內穩
The binding of ?-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using ?-arrestin as a scaffold, with sub
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
Tyrosine Kinase Assay Using Synthetic Peptides (T. Miller)Small synthetic peptide substrates are especially well suited for applications such as