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Apoptosis is specifically induced via signaling through a family of receptors known collectively as 'death receptors' including Fas, TNFR, DR3, -4 and -5. Death receptor ligands characteristically initiate signaling via receptor oligomerization, recruitment of specialized adaptor proteins and activation of caspase cascades. Apo3L recruits initiator caspase 8 via the adapter protein FADD. Caspase 8 then oligom......閱讀全文
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
蛋白酶caspase-8同時具有誘導和抑制細胞死亡的功能：它可以通過死亡受體（Death receptor），比如TNFR1來誘導細胞凋亡（Apoptosis）【1】，同時，也可以通過激酶RIPK3和MLKL來抑制細胞壞死（Necroptosis）【2-4】。caspase-8缺失或者突變（CA
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Nicotinic acetylcholine receptors are essential for neuromuscular signaling and are also expressed in non-neuronal tissues, where their function is le
One mechanism used by cytotoxic T cells to kill tumor cells and virus-infected cells is the release of perforin and granzyme proteins. Perforin protei
Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, a
The tumor necrosis factor (TNF) receptor superfamily contains several members with homologous cytoplasmic domains known as death domains (DD). The int
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
The IL-2 receptor is a key component of immune signaling and is required for the activation, proliferation, and survival of T cells. This receptor is
血液腫瘤主要包括各類白血病、多發性骨髓瘤以及惡性淋巴瘤。急性白血病占常見惡性腫瘤的第八位，淋巴瘤也是在前十位，并且發病率逐年升高，多發性骨髓瘤的整個發病率在血液惡性腫瘤里面占10%。 血液腫瘤發病急，在傳統的放療、化療、骨髓移植等治療方式下，治療周期長、費用高昂、過程痛苦，但治愈率卻并不很
二、細胞實驗效果不錯，那動物實驗怎么做？穩定性、重復性較好的動物模型可在腫瘤基礎性研究和抗腫瘤藥物篩選中發揮重要作用。血液腫瘤常用的動物模型主要有：I皮下移植瘤模型；II血液模型。皮下移植瘤模型較容易建立，易于動態觀察腫瘤的生長狀態。血液模型則一般以生存天數作為觀察終點，用活體成像、病理切片、流式細
在免疫學實驗中，比如WB，IHC，IF等，大家都知道選著好正確的一抗，往往實驗就成功了一大半，因此，往往很多研究者便會忽視對二抗，以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品，包裝大，因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話，影響的可能就是一整個實驗室或者課題組了。艾美
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS,
IntroductionMature T cells recognize and respond to the antigen/MHC complex through their antigen-specific receptors (TCR). The most immediate consequ
In Vitro T Cell ActivationIntroductionMature T cells recognize and respond to the antigen/MHC complex through their antigen-specific receptors (TCR).
IntroductionMature T cells recognize and respond to the antigen/MHC complex through their antigen-specific receptors (TCR). The most immediate consequ
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
ObjectiveThe objective of the experiment is to determine the effects of ethanol exposure on the embryonic development of zebrafish through observation
3 膽汁淤滯性肝病在許多臨床綜合征中可以觀察到膽汁淤滯，膽汁淤滯是一組慢性進行肝病的主要特征，并可最終導致肝硬化、肝衰竭和死亡。肝內疏水的毒性膽鹽儲滯長期以來被認為是肝損傷的一個主要原因，并被認為是膽汁淤滯性肝病肝損傷的一個關鍵原因。事實上肝內毒性膽鹽：鵝脫氧膽酸和脫氧膽酸鹽的儲滯水平與肝損傷的程度
IntroductionFetal Alcohol Syndrome (FAS) is caused by exposure of the developing embryo to alcohol, one of several teratogenic agents which adversely
Programmed cell death is induced by many different factors and involves numerous signaling pathways, some dependent on caspase proteases and others th
MATERIALS:1. 1 X PBS (PBSAz, 1 X PBS, e.g., Irvine Scientific, CA, containing 2% newborn calf serum and 0.1% sodium azide)2. 7-Amino-actinomycin D (7-
Chemical Induction of Apoptosis - 1 May 2001p53, p21WAF1, Myc, Bcl-2, Bax, Bcl-x and bak are among the proteins involved in the regulation of apoptosi
Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present
Nuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine n
The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure
Abstract Choriallantoic membrane (CAM) limb grafting functions as a method to isolate the inductive eve
【關鍵詞】 肝細胞 肝細胞凋亡的病理學特征為肝細胞的嗜酸性變，又稱嗜酸性壞死。表現為個別肝細胞胞漿的嗜伊紅性增強，胞核固縮直至消失，形成嗜酸小體（eosinophilic body），脫離肝細胞索墜入肝竇或竇間隙。周圍可出現CTL、枯否細胞，將凋亡小體
Maintaining the integrity of the gastrointestinal tract despite the continual presence of microbial flora and injurious agents is essential. Epithelia