WIKI資訊
Many key signaling molecules are conserved from yeast to man. mTOR is a protein kinase involved in nutrient and growth factor signaling in humans that has a yeast homolog with a similar role, TOR1. Like its human counterpart, yeast TOR1 is also inhibited by rapamycin. Signaling downstream of the TOR kinase pathways regulates the nuclear localization of several transcription factors in response to the carbon and nitro......閱讀全文
經過特殊的算法，我們得到了2018年前10個月中國生物醫學風云榜人物及最火爆的3個重大學術界事件，能夠上榜的風云人物/事件，都曾長時間占據過100多個公生物醫學公眾號的頭版頭條。 在此，我們精選了其中的3個事件及16位風云榜人物。我們對其進行了劃分，分別是：6星級的3個事件，分別位諾貝爾獎，國
mTOR (mammalian target of rapamycin) appears to play a central role in signaling caused by nutrients and mitogens such as growth factors to regulate t
Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size o
While transcriptional regulation is often viewed as the most prevalent way extracellular signals to regulate gene expression, post-transcriptional reg
Eukaryotic cells take up constituents of the extra-cellular environment and regulate the cell-surface level of membrane proteins via a recycling syste
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
The chromatin packaging of the genome is dynamic, changing with the cell cycle and with transcriptional regulation. During mitosis, chromatin is conde
Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors,
FL3500雙調制葉綠素熒光儀 （新升級型號為FL6000） FL3500雙調制葉綠素熒光儀是專門用于對藍綠藻或綠藻等微藻，葉綠體或類囊體懸浮物，乃至葉片進行光合作用研究的強大科研工具。儀器具備雙通道測量控制，可控制測量樣品的溫度，并配備單翻轉光（STF），內置多種可用戶自行修改的測量程序
Figure 5: Regulation of CDH5 by TFZFs in several human cancer cell lines.Blue, cells infected with a pMX construct containing the DNA bindin
TNF acts on several different signaling pathways through two cell surface receptors, TNFR1 and TNFR2 (See TNFR1 and TNFR2 Signaling Pathways) to regul
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
在免疫學實驗中，比如WB，IHC，IF等，大家都知道選著好正確的一抗，往往實驗就成功了一大半，因此，往往很多研究者便會忽視對二抗，以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品，包裝大，因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話，影響的可能就是一整個實驗室或者課題組了。艾美
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals
While T cells and B cells carry out the actions of antigen-specific immune responses, antigen-presenting cells called dendritic cells are required for
Sonic Hedgehog (Shh) is one of a family of three secreted proteins, including Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), that play distinct and
Hypertrophy associated with both hypertension and obstruction to ventricular outflow leads to pathologic cardiac growth and it is associated with incr
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
7 展望選擇性微電極技術能用于直接并靈敏地觀察植物體對礦質元素的需求，研究者可利用選擇性微電極技術進行對植物某種離子或高或低的吸收的品種的篩選，還可制定出與植物需求相適應的環境的營養水平；能及時準確地探測到的光、溫、水澇、鹽分引起的植物體離子或分子信息的微小變化，能成為預測植物受到逆境脅
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. C
2.2 Interaction mating - large scaleWith a few modifications, the procedure described above can be used to test for interactions between a single prey
Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF a
The eicosanoids are a family of lipophilic hormones derived from the twenty carbon fatty acid arachidonic acid. Although they are diverse in structure
Ang II-stimulated Cardiac Dysfunction in ARKO Male Mice-We also evaluated the cardiac performance of these mice using echocardiography. Although l
Sterol-regulatory element binding proteins (SREBPs) play a key role in transcriptional regulation of cholesterol metabolism in response to cholesterol
4. 注釋( 1 ) 每個實驗均使用新鮮的 3 mol/L 甲醇- HCl 和硅烷化試劑。( 2 ) 要仔細識別蛋白質印跡，因為 WGA 既能識別 N-糖苷的 GlcNAc，也能識別 O-GlcNAc。( 3 ) 用于在硝酸纖維素印跡膜上封閉結合位點的溶液應避免糖蛋白污染。所以我們建議在這一步驟中使
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate