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The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection. One mechanism of signaling by these GPCRs is through activation of Gi signaling. These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway. This pathway elevates calcium influx into the cell through CRAC channels, ion......閱讀全文
CXCR4 is a chemokine receptor in the GPCR gene family, and is expressed by cells in the immune system and the central nervous system. In response to b
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these ce
在免疫學實驗中，比如WB，IHC，IF等，大家都知道選著好正確的一抗，往往實驗就成功了一大半，因此，往往很多研究者便會忽視對二抗，以及其它試劑盒品質的追求。二抗是一種相對而言比較穩定的產品，包裝大，因此很多實驗室都會公用一個二抗。但如果二抗沒有選擇好的話，影響的可能就是一整個實驗室或者課題組了。艾美
人類免疫缺陷病毒（human immunodeficiency virus, HIV），即艾滋病（AIDS，獲得性免疫缺陷綜合征）病毒，是造成人類免疫系統缺陷的一種病毒。1983年，美國馬里蘭大學醫學院的Robert Gallo團隊[1][2]和法國巴斯德研究所的Luc Montagnier團隊
T helper cells play an essential role coordinating the activities of other parts of the immune system, including B cells, cytotoxic T cells, macrophag
截止2020月7月27日，中國學者在Cell，Nature 及Science 發表了共計102項生命科學的研究成果，其中新冠肺炎領域占了近一半（共43篇）。iNature系統總結了這些研究成果： 按雜志來劃分：Cell 發表了30篇，Nature 發表了45篇，
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic cel
Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic signals
第一版（2010年9月）前言 醫學論文設計水平的新穎性和創新性，是決定撰寫的醫學論文能否被SCI醫學雜志編委和主編認同的第一門道；醫學論文撰寫水平的邏輯性和規范性，則是決定撰寫的醫學論文能否被SCI醫學雜志接受的最終門道。發表SCI期刊醫學論文的語言是英語，對于母語是非英語的中國臨床醫生
第一版（2010年9月）前言 醫學論文設計水平的新穎性和創新性，是決定撰寫的醫學論文能否被SCI醫學雜志編委和主編認同的第一門道；醫學論文撰寫水平的邏輯性和規范性，則是決定撰寫的醫學論文能否被SCI醫學雜志接受的最終門道。發表SCI期刊醫學論文的語言是英語，對于母語是非英語的中國臨床醫生
簡明SCI期刊醫學論文撰寫手冊 第一版（2010年9月）前言 醫學論文設計水平的新穎性和創新性，是決定撰寫的醫學論文能否被SCI醫學雜志編委和主編認同的第一門道；醫學論文撰寫水平的邏輯性和規范性，則是決定撰寫的醫學論文能否被SCI醫學雜志接受的最終門道。發表SCI期刊醫學論文的語言
血糖監測是糖尿病管理的重要內容。已有多項大型臨床研究證實，糖化血紅蛋白（HbA1c）與糖尿病慢性并發癥的發生存在關聯，將HbA1c水平控制在合適的范圍內可以有效降低慢性并發癥的風險，因此，長久以來HbA1c一直被視作評價糖尿病患者長期血糖控制狀況的金標準[1]。然而，血紅蛋白的更新速度異常，某些情況
Low-density lipoprotein (LDL) is a plasma lipoprotein particle whose lipid component includes cholesterol and triglycerides and is commonly referred t
本周又有一期新的Science期刊（2017年6月9日）發布，它有哪些精彩研究呢？讓小編一一道來。 1.Science：針對藥物BIA 10-2474的神經毒性提出一種潛在的新解釋 doi:10.1126/science.aaf7497 如今，在一項新的研究中，來自荷蘭、美國和意大利的一個
第二代高通量藥物篩選平臺更容易發現磷脂酰肌醇信號通路低親合力抑制劑EJ Dell1, JL Tardieu2, F. Degorce2, Michael Fejtl11 BMG LABTECH Inc. NC, USA edward.dell@bmglabtech.com2 Cisbio Bioas
HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be c
ABSTRACTFibroblast growth factor (FGF) signaling plays a signifigant role in embryonic development. Particularyl, FGFs are implicated in mediating epi
Thrombin is an extracellular protease that is involved in the clotting of blood and inflammation through its action on platelets and endothelial cells
2019年12月24日，頂級醫學期刊 Nature Medicine 雜志發表題為：No statistical evidence for an effect of CCR5-Δ32 on lifespan in the UK Biobank cohort 的文章【1】。 該文章稱，沒有統計證
A Method for Structure–Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable StreptococciMany species of streptococci se
Sonic Hedgehog (Shh) is one of a family of three secreted proteins, including Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), that play distinct and
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
The hepatocyte growth factor receptor, also called c-Met, is activated by HGF and stimulates proliferation of hepatocytes and other cell types. Mutate
ConclusionsQuorum-sensing signaling systems involving the interaction between a signaling peptide and its cognate histidine kinase receptor are widely
As with many cell-surface receptors, activation of the EGF receptor can result in receptor internalization through receptor-mediated endocytosis, dese
MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2aMicroRNAs are positive and negative r
The G-protein coupled receptor (GPCR) family transduces extracellular signals across the plasma membrane, activating cellular responses through a vari